As mass vaccination campaigns against coronavirus disease 2019 (COVID-19) commence worldwide, vaccine effectiveness needs to be assessed for a range of outcomes across diverse populations in a non-controlled setting. A study published in the New England Journal of Medicine cited data from Israel’s largest health care organization to evaluate the effectiveness of the BNT162b2 mRNA vaccine. The study evaluated the …
Autoimmune diseases such as Multiple Sclerosis (MS), result from a breath of immunological self-tolerance and tissue damage by autoreactive T lymphocytes. Current treatments can cause systemic immune suppression and side effects such as an increased risk of infections. Krienke et al. designed a messenger RNA vaccine strategy that lacks adjuvant activity and delivers MS autoantigens into lymphoid cells. This approach …
